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Noggin Rekombinanter Antikörper

Noggin Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241511D10

Kat-Nr. : 84283-5-PBS

Synonyme

NOG, SYNS1, SYM1, 241511D10

Filter:
  • Western Blot (WB) analysis of various lysates using Noggin Recombinant antibody (84283-5-RR)

    WB analysis using 84283-5-RR (same clone as 84283-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84283-5-RR (NOG antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84283-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84283-5-RR

    Affinity and Kinetic Characterization of 84283-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84283-5-RR against Human Noggin were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

84283-5-PBS bindet in WB, Indirect ELISA Noggin und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Noggin fusion protein Ag32755
Vollständiger Name noggin
Berechnetes Molekulargewicht 26 kDa
Beobachtetes Molekulargewicht 26 kDa
GenBank-ZugangsnummerBC034027
Gene symbol Noggin
Gene ID (NCBI) 9241
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Noggin is an extracellular polypeptide acting as an antagonist of bone morphogenetic proteins (BMPs) regulating embryonal development. Noggin inhibits activity of BMP-2, -4, -7, -13, and -14. Noggin is present extracellularly in the matrix or retained at the cell surface via interaction with heparin sulfate proteoglycans. In early development stages, Noggin is produced by the Spemann organizer, allowing dorsal-ventral patterning of BMPs (PMID: 8752214). Subsequently, Noggin is expressed by the notochord regulating BMP-4 signaling in neurogenesis. Additionally, Noggin is present during development in the dermal papilla, connective tissue of the hair follicle, lens, retina, and periocular mesenchyme, as well as in the mesoderm lineage regulating development of the bone, cartilage, and muscles.