OFD1 Polyklonaler Antikörper

OFD1 Polyklonal Antikörper für IHC, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IHC, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 22851-1-PBS

Synonyme

71 7A, Centriole and centriolar satellite protein OFD1, CXorf5, Oral-facial-digital syndrome 1 protein, Protein 71 7A

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  IHC staining of human brain using 22851-1-AP (same clone as 22851-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human brain slide using 22851-1-AP (OFD1 Antibody) at dilution of 1:50. (under 10x lens). This data was developed using the same antibody clone with 22851-1-PBS in a different storage buffer formulation.

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  IHC staining of human brain using 22851-1-AP (same clone as 22851-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human brain slide using 22851-1-AP (OFD1 Antibody) at dilution of 1:50. (under 40x lens). This data was developed using the same antibody clone with 22851-1-PBS in a different storage buffer formulation.

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  IF Staining of HEK-293 using 22851-1-AP (same clone as 22851-1-PBS)

  Immunofluorescent analysis of (-20°C Ethanol) fixed HEK-293 cells using OFD1 antibody (22851-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 22851-1-PBS in a different storage buffer formulation.

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  IF Staining of hTERT-RPE1 using 22851-1-AP (same clone as 22851-1-PBS)

  Immunofluorescent analysis of (-20°C Methanol) fixed hTERT-RPE1 cells using OFD1 antibody (22851-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2), CoraLite®594 ARL13B antibody (CL594-17711, red). This data was developed using the same antibody clone with 22851-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

22851-1-PBS bindet in IHC, IF/ICC, Indirect ELISA OFD1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: OFD1 fusion protein Ag18898
• Vollständiger Name: oral-facial-digital syndrome 1
• Berechnetes Molekulargewicht: 1012 aa, 117 kDa
• Beobachtetes Molekulargewicht: 110-120 kDa
• GenBank-Zugangsnummer: BC096344
• Gene symbol: OFD1
• Gene ID (NCBI): 8481
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

OFD1, also named CXorf5 and 71-7A, belongs to the OFD1 family. It has been implicated in several developmental syndromes, including a male-lethal X-linked dominant condition, Oral-Facial-Digital type 1 (OFD1) syndrome, X-linked recessiveSimpson-Golabi-Behmel syndrome type 2 (SGBS2), and Joubert syndrome and related disorders (JSRDs). It is a component of the centrioles controlling mother and daughter centrioles' length. It recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. OFD1 plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. This antibody recognizes all the isoforms of OFD1. The 43 kDa is isoform 2. The ~80 kDa band is unknown.