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- KD/KO Validated
OPTN/Optineurin Monoklonaler Antikörper
OPTN/Optineurin Monoklonal Antikörper für WB, IHC, IF/ICC, Indirect ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
Hausschwein, human
Anwendung
WB, IHC, IF/ICC, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
6C1H4
Kat-Nr. : 60293-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
60293-1-PBS bindet in WB, IHC, IF/ICC, Indirect ELISA OPTN/Optineurin und zeigt Reaktivität mit Hausschwein, human
Getestete Reaktivität | Hausschwein, human |
Wirt / Isotyp | Maus / IgG1 |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | OPTN/Optineurin fusion protein Ag1272 |
Vollständiger Name | optineurin |
Berechnetes Molekulargewicht | 66 kDa |
Beobachtetes Molekulargewicht | 70-74 kDa |
GenBank-Zugangsnummer | BC013876 |
Gene symbol | OPTN |
Gene ID (NCBI) | 10133 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-G-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
OPTN, also named as FIP2, GLC1E, HIP7, HYPL and NRP, plays a neuroprotective role in the eye and optic nerve. It is probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). OPTN may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG). OPTN mutated in adult-onset primary open angle glaucoma. It supports the protective role of OPTN in the trabecular meshwork.