• Featured Product
  • KD/KO Validated

OPTN/Optineurin Monoklonaler Antikörper

OPTN/Optineurin Monoklonal Antikörper für WB, IHC, IF/ICC, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

Hausschwein, human

Anwendung

WB, IHC, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

6C1H4

Kat-Nr. : 60293-1-PBS

Synonyme

Optineurin, OPTN, 6C1H4, ALS12, E3-14.7K-interacting protein



Geprüfte Anwendungen

Produktinformation

60293-1-PBS bindet in WB, IHC, IF/ICC, Indirect ELISA OPTN/Optineurin und zeigt Reaktivität mit Hausschwein, human

Getestete Reaktivität Hausschwein, human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen OPTN/Optineurin fusion protein Ag1272
Vollständiger Name optineurin
Berechnetes Molekulargewicht 66 kDa
Beobachtetes Molekulargewicht 70-74 kDa
GenBank-ZugangsnummerBC013876
Gene symbol OPTN
Gene ID (NCBI) 10133
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

OPTN, also named as FIP2, GLC1E, HIP7, HYPL and NRP, plays a neuroprotective role in the eye and optic nerve. It is probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). OPTN may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG). OPTN mutated in adult-onset primary open angle glaucoma. It supports the protective role of OPTN in the trabecular meshwork.