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ORP1L Polyklonaler Antikörper

ORP1L Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 25268-1-PBS

Synonyme

ORP1, ORP 1, OSBPL1A, OSBPL1, OSBP8

Filter:
  • Western Blot (WB) analysis of various lysates using ORP1L Polyclonal antibody (25268-1-AP)

    WB analysis using 25268-1-AP (same clone as 25268-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 25268-1-AP (ORP1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25268-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

25268-1-PBS bindet in WB, Indirect ELISA ORP1L und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name oxysterol binding protein-like 1A
Berechnetes Molekulargewicht 108 kDa
Beobachtetes Molekulargewicht50 kDa, 105-110 kDa
GenBank-ZugangsnummerNM_018030
Gene symbol OSBPL1A
Gene ID (NCBI) 114876
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ORP1L (Oxysterol-binding protein-related protein 1L) is a lipid transfer protein that belongs to the family of OSBP-related proteins (ORPs). It is recruited to lysosomes via its ankyrin repeat domains that bind to Rab7(PMID: 34504082). ORP1L also possesses an FFAT motif, which allows it to interact with the ER resident VAP proteins to aid in establishing the ER-lysosomes contacts. ORP1L is expressed in various tissues, with particularly high expression in the brain, lungs, and macrophages. ORP1L plays a crucial role in cholesterol homeostasis. Disruption of ORP1L function can lead to a block in cholesterol transport to the ER, resulting in the accumulation of cholesterol-enriched LELs in the Golgi/perinuclear region. This can disrupt cellular cholesterol balance, potentially contributing to various metabolic diseases. This suggests that ORP1L is necessary for the normal functioning of cholesterol export from the endo-lysosomal system to the ER, and its dysfunction could be implicated in the progression of diseases related to cholesterol metabolism dysregulation(PMID: 28564600). The molecular weight of ORP1L is 50 kDa.