OSMR Polyklonaler Antikörper

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• KD/KO Validated

OSMR Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Affe, human und mehr (1)

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

9

Kat-Nr. : 10982-1-AP

Synonyme

IL 31 receptor subunit beta, IL 31R beta, IL 31R subunit beta, IL 31RB, oncostatin M receptor, OSMR, OSMR β, OSMRB, OSMRβ

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Galerie der Validierungsdaten

• 

  WB analysis using 10982-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 10982-1-AP (OSMR antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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  WB analysis of HeLa using 10982-1-AP

  WB result of OSMR antibody (10982-1-AP; 1:300; incubated at room temperature for 1.5 hours) with sh-Control and sh-OSMR transfected HeLa cells.

• 

  WB analysis of A375 using 10982-1-AP

  A375 cells were subjected to SDS PAGE followed by western blot with 10982-1-AP (OSMR antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

• 

  WB analysis of HEK-293T using 10982-1-AP

  HEK-293T cells were subjected to SDS PAGE followed by western blot with 10982-1-AP (OSMR antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HeLa-Zellen, A375-Zellen, HEK-293T-Zellen, HepG2-Zellen, Raji-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 2 publications below
• WB: See 5 publications below
• IHC: See 2 publications below
• IF: See 2 publications below

Produktinformation

10982-1-AP bindet in WB, IHC, IF, ELISA OSMR und zeigt Reaktivität mit Affe, human

• Getestete Reaktivität: Affe, human
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: OSMR fusion protein Ag1426
• Vollständiger Name: oncostatin M receptor
• Berechnetes Molekulargewicht: 110 kDa
• Beobachtetes Molekulargewicht: 110 kDa
• GenBank-Zugangsnummer: BC010943
• Gene symbol: OSMR
• Gene ID (NCBI): 9180
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Oncostatin M (OSM) is a member of interleukin-6 family cytokines that modulates proliferation and differentiation in numerous cells (PMID: 22982441). OSM signals via a receptor complex comprising gp130 and the OSMR (also refered to as OSMRβ) (PMID: 8999038). OSMR is a single-pass membrane protein that belongs to the type I cytokine receptor family. OSMR mRNA is expressed at relatively high levels in all neural cells and fibroblast, epithelial, and various tumor cell lines (PMID: 8999038). It has also been shown that OSMR associates with IL31RA to form the heterodimeric IL31 receptor (PMID: 15184896). A 70 kDa soluble form can be detected by western blot (PMID: 17028186).

Publikationen

Species	Application	Title
human,mouse	WB	Cell Stem Cell; Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling.; Authors - Kubin Thomas T
mouse,human	IF	Sci Adv; Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart.; Authors - Melissa Valussi ; KO Validated
	IF	Br J Dermatol; CD11b+ cells markedly express the itch cytokine interleukin-31 in polymorphic light eruption.; Authors - V Patra
human	WB	Aging (Albany NY); Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma.; Authors - Jing-Yuan Cao
mouse	WB	Stem Cell Res Ther; Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling.; Authors - Jie Zhou ; KD Validated
human	IHC	Acta Derm Venereol; IL-31 expression by inflammatory cells is preferentially elevated in atopic dermatitis.; Authors - Nobbe Stephan S

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