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OTUB2 Polyklonaler Antikörper

OTUB2 Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 12066-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using OTUB2 Polyclonal antibody (12066-1-AP)

    WB analysis using 12066-1-AP (same clone as 12066-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12066-1-AP (OTUB2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12066-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of U2OS cells using OTUB2 Polyclonal antibody (12066-1-AP)

    IF Staining of U2OS using 12066-1-AP (same clone as 12066-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U2OS cells using OTUB2 antibody (12066-1-AP) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002), CL594-phalloidin (red). This data was developed using the same antibody clone with 12066-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

12066-1-PBS bindet in WB, IF/ICC, Indirect ELISA OTUB2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen OTUB2 fusion protein Ag2703
Vollständiger Name OTU domain, ubiquitin aldehyde binding 2
Berechnetes Molekulargewicht 234 aa, 27 kDa
Beobachtetes Molekulargewicht27 kDa
GenBank-ZugangsnummerBC009615
Gene symbol OTUB2
Gene ID (NCBI) 78990
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

OTUB2, also known as C14orf137, belongs to the OTU family. OTUB2 is a functional cysteine protease with deubiquitinase activity. OTUB2 mediates the deubiquitination of substrate proteins, and the targets of substrate proteins can be diversified. Therefore, OTUB2 has a wide range of biological roles, including protecting against virus-induced activation of interferon regulatory factor 3 (IRF3) and NF-κB, promoting beta cell survival in human pancreatic islets, and supporting the DNA repair pathway (PMID: 30662561, 35309903). OTUB2 is widely expressed, with high expression levels in the brain. OTUB2 has 2 isoforms with molecular weights of 9 kDa and 27 kDa.