OTUD5 Polyklonaler Antikörper

OTUD5 Polyklonal Antikörper für WB, IF/ICC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IF/ICC, IP, CoIP, ELISA

Konjugation

Unkonjugiert

Publikationen(8)

Kat-Nr. : 21002-1-AP

Synonyme

OTUD 5, OTU domain-containing protein 5, EC:3.4.19.12, DUBA



Geprüfte Anwendungen

Erfolgreiche Detektion in WBHEK-293T-Zellen, C6-Zellen, HEK-293-Zellen, HeLa-Zellen, Jurkat-Zellen, K-562-Zellen, NIH/3T3-Zellen
Erfolgreiche Detektion in IF/ICCA431-Zellen

Empfohlene Verdünnung

AnwendungVerdünnung
Western Blot (WB)WB : 1:500-1:3000
Immunfluoreszenz (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

21002-1-AP bindet in WB, IF/ICC, IP, CoIP, ELISA OTUD5 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
In Publikationen genannte Reaktivitäthuman, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen OTUD5 fusion protein Ag15190
Vollständiger Name OTU domain containing 5
Berechnetes Molekulargewicht 571 aa, 61 kDa
Beobachtetes Molekulargewicht70-75 kDa
GenBank-ZugangsnummerBC028225
Gene symbol OTUD5
Gene ID (NCBI) 55593
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS with 0.02% sodium azide and 50% glycerol
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The deubiquitinating enzyme OTUD5, also known as deubiquitinating enzyme A (DUBA), is a member of the deubiquitinating enzyme OTU family. By deubiquitinating other proteins, OTUD5 is an important regulator of several physiological processes, such as immune signaling and DNA damage responses. The dysregulation of these processes can increase the risk of associated diseases, including inflammation, cancer and genetic disorders.

Protokolle

PRODUKTSPEZIFISCHE PROTOKOLLE
WB protocol for OTUD5 antibody 21002-1-APProtokoll herunterladen
IF protocol for OTUD5 antibody 21002-1-APProtokoll herunterladen
STANDARD-PROTOKOLLE
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle
human,mouseWB,IP,IF

Nat Commun

OTUD5 promotes end-joining of deprotected telomeres by promoting ATM-dependent phosphorylation of KAP1S824

Authors - Shiu Yeung Lam
human,mouseWB,IF

Adv Sci (Weinh)

OTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model

Authors - Xiaomeng Song
humanWB,IF

Clin Transl Med

p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer

Authors - Junjing Zhang
  • KD Validated
human,mouseWB

Int J Radiat Oncol Biol Phys

USP11 exacerbates radiation induced pneumonitis by activating endothelial cell inflammatory response via OTUD5-STING signaling

Authors - Yiting Tang
humanWB

Carcinogenesis

CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5

Authors - Mixue Bai
mouseWB,IF,CoIP

Nat Commun

Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury

Authors - Ying Zhao