Osteoprotegerin/TNFRSF11B Polyklonaler Antikörper

Osteoprotegerin/TNFRSF11B Polyklonal Antikörper für WB, IHC, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 11534-1-PBS

Synonyme

Tumor necrosis factor receptor superfamily member 11B, TNFRSF11B, Osteoprotegerin, Osteoclastogenesis inhibitory factor, OPG

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  WB analysis of human milk using 11534-1-AP (same clone as 11534-1-PBS)

  human milk was subjected to SDS PAGE followed by western blot with 11534-1-AP (Osteoprotegerin/TNFRSF11B antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11534-1-PBS in a different storage buffer formulation.

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  WB analysis of human milk using 11534-1-AP (same clone as 11534-1-PBS)

  human milk was subjected to SDS PAGE followed by western blot with 11534-1-AP (Osteoprotegerin antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11534-1-PBS in a different storage buffer formulation.

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  IHC staining of rat kidney using 11534-1-AP (same clone as 11534-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using 11534-1-AP (Osteoprotegerin/TNFRSF11B antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11534-1-PBS in a different storage buffer formulation.

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  IHC staining of rat kidney using 11534-1-AP (same clone as 11534-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using 11534-1-AP (Osteoprotegerin/TNFRSF11B antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11534-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 11534-1-AP (same clone as 11534-1-PBS)

  Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using Osteoprotegerin antibody (11534-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 11534-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

11534-1-PBS bindet in WB, IHC, IF/ICC, Indirect ELISA Osteoprotegerin/TNFRSF11B und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Osteoprotegerin/TNFRSF11B fusion protein Ag2139
• Vollständiger Name: tumor necrosis factor receptor superfamily, member 11b
• Berechnetes Molekulargewicht: 401 aa, 46 kDa
• Beobachtetes Molekulargewicht: 56 kDa
• GenBank-Zugangsnummer: BC030155
• Gene symbol: TNFRSF11B
• Gene ID (NCBI): 4982
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Osteoprotegerin (OPG), also known as tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) and osteoclastogenesis inhibitory factor (OCIF), belongs to the tumor necrosis factor (TNF) receptor superfamily. By binding to RANKL, OPG inhibits osteoclastic activity and promoting bone formationis. OPG plays a key role on cell survival by inhibiting TRAIL-induced apoptosis. OPG also is involved in vascular biology, fibrosis, immunity, EMT, and the apoptosis of cancer cells (PMID: 35523775).