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PALB2 Polyklonaler Antikörper

PALB2 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 14340-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using PALB2 Polyclonal antibody (14340-1-AP)

    WB analysis using 14340-1-AP (same clone as 14340-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 14340-1-AP (PALB2 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14340-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using PALB2 Polyclonal antibody (14340-1-AP)

    IHC staining of human breast cancer using 14340-1-AP (same clone as 14340-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 14340-1-AP (PALB2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14340-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

14340-1-PBS bindet in WB, IHC, Indirect ELISA PALB2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen PALB2 fusion protein Ag5654
Vollständiger Name partner and localizer of BRCA2
Berechnetes Molekulargewicht 131 kDa
Beobachtetes Molekulargewicht 130 kDa; 80-90 kDa; 250-260 kDa
GenBank-ZugangsnummerBC044254
Gene symbol PALB2
Gene ID (NCBI) 79728
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PALB2 can interact with BRCA1 and BRCA2 and form the BRCA1-PALB2-BRCA2 complex which is critical for homologous recombination and DNA damage response. PALB2 is an essential partner of BRCA2 that promotes the localization and stability of BRCA2. The predicted MW of PALB2 is approximately 130 kDa, while the truncated PALB2 protein arround 80-90 kDa can also be detected in SDS-PAGE similar to papers. (PubMed:16793542, 24141787, 24153426). There's the dimer form with MW 250-260 kDa (refer to PMID: 30289697).