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PAR2 Polyklonaler Antikörper

PAR2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 12160-1-PBS

Synonyme

PAR 2, G-protein coupled receptor 11, GPR11, G protein coupled receptor 11, F2RL1

Filter:
  • Western Blot (WB) analysis of various lysates using PAR2 Polyclonal antibody (12160-1-AP)

    WB analysis using 12160-1-AP (same clone as 12160-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12160-1-AP (PAR2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12160-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

12160-1-PBS bindet in WB, Indirect ELISA PAR2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen PAR2 fusion protein Ag2801
Vollständiger Name coagulation factor II (thrombin) receptor-like 1
Berechnetes Molekulargewicht 397 aa, 44 kDa
Beobachtetes Molekulargewicht 50-55 kDa
GenBank-ZugangsnummerBC018130
Gene symbol PAR2
Gene ID (NCBI) 2150
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Proteinase-activated receptors (PARs) are G protein-coupled receptors activated through cleavage of their N-termini by mainly serine proteases. The family of PARs includes four members: PAR1, PAR2, PAR3, and PAR4. PAR2, also known as F2RL1, is expressed in epithelial cells (e.g., lung, gastrointestinal tract), endothelial cells, smooth muscle cells, fibroblasts, nerves, and some immune and inflammatory cells. PAR2 knockout mice and PAR2 agonists and antagonists have implicated PAR2 as a promising target in inflammatory conditions; respiratory, gastrointestinal, metabolic, cardiovascular, and neurological dysfunction; and cancers. (PMID:23895492)