PARK7/DJ-1 Rekombinanter Antikörper
PARK7/DJ-1 Rekombinant Antikörper für ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
ELISA
Konjugation
Unkonjugiert
CloneNo.
230124B3
Kat-Nr. : 82913-3-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
82913-3-PBS bindet in ELISA PARK7/DJ-1 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Rekombinant |
| Typ | Antikörper |
| Immunogen | PARK7/DJ-1 fusion protein Ag2287 |
| Vollständiger Name | Parkinson disease (autosomal recessive, early onset) 7 |
| Berechnetes Molekulargewicht | 189 aa, 20 kDa |
| Beobachtetes Molekulargewicht | 20 kDa |
| GenBank-Zugangsnummer | BC008188 |
| Gene symbol | PARK7 |
| Gene ID (NCBI) | 11315 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Protein A purfication |
| Lagerungspuffer | PBS only |
| Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
PARK7, also named as DJ1, belongs to the peptidase C56 family. It protects cells against oxidative stress and cell death. PARK7 plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. It eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. PARK7 has cell-growth promoting activity and transforming activity. It may function as a redox-sensitive chaperone. It's precursor undergoes a cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress. The amino acid replace at 166 (L → P) reduces PARK7 protein stability and leads to increased degradation. The predicted MW of this protein is 20 kDa, An additional 25 kDa band can be observed due to modification (PMID: 31767755).
