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PARL Rekombinanter Antikörper

PARL Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242171C12

Kat-Nr. : 85167-1-PBS

Synonyme

PRO2207, Presenilin-associated rhomboid-like protein, mitochondrial, P-beta, Pbeta, EC:3.4.21.105

Filter:
  • Western Blot (WB) analysis of MCF-7 cells using PARL Recombinant antibody (85167-1-RR)

    WB analysis of MCF-7 using 85167-1-RR (same clone as 85167-1-PBS)

    MCF-7 cells were subjected to SDS PAGE followed by western blot with 85167-1-RR (PARL antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85167-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using PARL Recombinant antibody (85167-1-RR)

    WB analysis using 85167-1-RR (same clone as 85167-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85167-1-RR (PARL antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85167-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85167-1-PBS bindet in WB, Indirect ELISA PARL und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen PARL fusion protein Ag24789
Vollständiger Name presenilin associated, rhomboid-like
Berechnetes Molekulargewicht 42 kDa
Beobachtetes Molekulargewicht45 kDa
GenBank-ZugangsnummerBC014058
Gene symbol PARL
Gene ID (NCBI) 55486
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PARL (Presenilin associated rhomboid like), is a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. PARL has 2 isoforms produced by alternative splicing with the molecular mass of 42 kDa and 37 kDa. PARL regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of PARL may result in the release of a small peptide, P-beta, which may transit to the nucleus. The self-regulated cleavage of PARL at positions 52-53 (α-site) and 77--78 (β-site) produce two cleaved forms of PARL named MAMP and PACT with the molecular mass of 36 kDa and 33 kDa respectively (PMID: 14732705, 28178523).