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PARP10 Rekombinanter Antikörper

PARP10 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

Konjugation

Unkonjugiert

CloneNo.

250454D4

Kat-Nr. : 86096-1-PBS

Synonyme

ADP-ribosyltransferase diphtheria toxin-like 10, ARTD10, EC:2.4.2.-, PARP 10, PARP-10

Filter:
  • Western Blot (WB) analysis of various lysates using PARP10 Recombinant antibody (86096-1-RR)

    WB analysis using 86096-1-RR (same clone as 86096-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86096-1-RR (PARP10 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86096-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86096-1-PBS bindet in PARP10 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen PARP10 fusion protein Ag23457
Vollständiger Name poly (ADP-ribose) polymerase family, member 10
Beobachtetes Molekulargewicht150 kDa
GenBank-ZugangsnummerBC136542
Gene symbol PARP10
Gene ID (NCBI) 84875
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PARP10 (Poly(ADP-ribose) polymerase family member 10) is a mono-ADP-ribosyltransferase that belongs to the PARP family. It regulates a variety of cellular functions, including gene transcription, DNA repair, and cell cycle control, by catalyzing ADP-ribosylation reactions. PARP10 is distributed in both the nucleus and cytoplasm, participating in the cellular response to DNA damage. In particular, its expression level significantly increases in response to UV-induced DNA damage. Additionally, PARP10 plays a crucial role in the antiviral response, being highly upregulated by interferon (IFN) to inhibit the replication of certain viruses and block protein translation during viral replication. PARP10 is also involved in immune regulation, interacting with NEMO to block the NF-κB signaling pathway and the production of pro-inflammatory cytokines.