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PAX7 Polyklonaler Antikörper

PAX7 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 20570-1-PBS

Synonyme

PAX7B, PAX-7, PAX 7, Paired box protein Pax-7, paired box 7

Filter:
  • Western Blot (WB) analysis of NCCIT cells using PAX7 Polyclonal antibody (20570-1-AP)

    WB analysis of NCCIT using 20570-1-AP (same clone as 20570-1-PBS)

    NCCIT cell were subjected to SDS PAGE followed by western blot with 20570-1-AP (PAX7 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20570-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

20570-1-PBS bindet in WB, Indirect ELISA PAX7 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name paired box 7
Berechnetes Molekulargewicht 57 kDa
Beobachtetes Molekulargewicht 57 kDa
GenBank-ZugangsnummerNM_002584
Gene symbol PAX7
Gene ID (NCBI) 5081
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Pax7 is a highly conserved transcription factor involved in early development of the neural crest and gastrulation and is a commonly used marker for satellite cells in muscle tissue. This antibody is specific to PAX7. It will not cross-react with other PAX protein family members.

What is the molecular weight of Pax7?

57 kDa

What is the role of Pax7?

One of the Paired Box (Pax) transcription factors, which are key in early development and organogenesis in vertebrates, Pax7 binds directly to DNA and is key in neural crest induction (PMID: 26410165). One of the earlier markers in this phase of embryogenesis, Pax7 therefore influences the migration and proliferation of multiple lineages of cells (PMID: 22848431).

In adult tissue, Pax7 is expressed by the quiescent resident muscle stem cells, also known as satellite cells, making it a useful marker for this cell type. It is essential for their formation and maintenance in their niche. When activated, these cells can proliferate in the normal maintenance of muscle tissue or respond to injury in repair. The co-expression of Pax7 with MyoD in these activated satellite cells regulates muscle cell proliferation (PMID: 16608873).

What proteins does Pax7 interact with?

An orthologue of Pax7, another transcription factor of the same family, is Pax3. These two proteins can form a heterodimer, binding to DNA to work together in myogenesis but can also function independently and have overlapping roles (PMID: 16380438).

What is the role of Pax7 in disease?

Pax7 and Pax 3 have both been identified in tumor tissue from the childhood cancer alveolar rhabdomyosarcoma (ARMS), which affects skeletal muscle (PMID: 23206814).