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PAX8 Monoklonaler Antikörper

PAX8 Monoklonal Antikörper für ELISA

Wirt / Isotyp

Maus / IgG2b

Getestete Reaktivität

human

Anwendung

ELISA

Konjugation

Unkonjugiert

CloneNo.

1C5A11

Kat-Nr. : 60144-1-Ig

Synonyme

Galerie der Validierungsdaten

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  • Immunohistochemistry (IHC) staining of human ovary tumor tissue using PAX8 Monoclonal antibody (60144-1-Ig)

    IHC staining of human ovary tumor using 60144-1-Ig

    Immunohistochemical analysis of paraffin-embedded human ovary tumor using 60144-1-Ig(PAX8 antibody) at dilution of 1:50 (under 40x lens).

  • Immunohistochemistry (IHC) staining of human ovary tumor tissue using PAX8 Monoclonal antibody (60144-1-Ig)

    IHC staining of human ovary tumor using 60144-1-Ig

    Immunohistochemical analysis of paraffin-embedded human ovary tumor using 60144-1-Ig(PAX8 antibody) at dilution of 1:50 (under 10x lens).

Geprüfte Anwendungen

Empfohlene Verdünnung

AnwendungVerdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

60144-1-Ig bindet in ELISA PAX8 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2b
Klonalität Monoklonal
Typ Antikörper
Immunogen PAX8 fusion protein Ag0306
Vollständiger Name paired box 8
Berechnetes Molekulargewicht 48 kDa
GenBank-ZugangsnummerBC001060
Gene symbol PAX8
Gene ID (NCBI) 7849
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas.

PAX8 has 5 isoforms with calculated MW 31kd, 34kd, 41kd, 43kd and 48kd. And there is a 60kd band corresponding to the electrophoretic mobility of PAX8 (PMID:15650356). Proteintech’s 10336-1-AP antibody has cross-reactivities with the other PAX family members.