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PAX8 Monoklonaler Antikörper

PAX8 Monoklonal Antikörper für Cytometric bead array, Indirect ELISA

Wirt / Isotyp

Maus / IgG2b

Getestete Reaktivität

human

Anwendung

Cytometric bead array, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1C5A11

Kat-Nr. : 60144-1-PBS

Synonyme

PAX-8, PAX 8, Paired box protein Pax-8, Paired box protein Pax 8, paired box 8

Filter:
  • Cytometric bead array standard curve of MP50408-4

    Cytometric bead array standard curve of MP50408-4

    Cytometric bead array standard curve of MP50408-4, PAX8 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 60144-1-PBS. Detection antibody: 68979-2-PBS. Standard:Ag0306. Range: 0.781-100 ng/mL.

  • Cytometric bead array standard curve of MP50408-5

    Cytometric bead array standard curve of MP50408-5

    Cytometric bead array standard curve of MP50408-5, PAX8 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 60144-1-PBS. Detection antibody: 68979-1-PBS. Standard:Ag0306. Range: 1.563-100 ng/mL.

Geprüfte Anwendungen

Produktinformation

60144-1-PBS bindet in Cytometric bead array, Indirect ELISA PAX8 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2b
Klonalität Monoklonal
Typ Antikörper
Immunogen PAX8 fusion protein Ag0306
Vollständiger Name paired box 8
Berechnetes Molekulargewicht 48 kDa
GenBank-ZugangsnummerBC001060
Gene symbol PAX8
Gene ID (NCBI) 7849
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas.

PAX8 has 5 isoforms with calculated MW 31kd, 34kd, 41kd, 43kd and 48kd. And there is a 60kd band corresponding to the electrophoretic mobility of PAX8 (PMID:15650356).