PAX8 Monoklonaler Antikörper
PAX8 Monoklonal Antikörper für WB, IHC, IF/ICC, IF-P, Indirect ELISA
Wirt / Isotyp
Maus / IgG2b
Getestete Reaktivität
human, Maus, Ratte
Anwendung
WB, IHC, IF/ICC, IF-P, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
4H7B3
Kat-Nr. : 60145-4-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
60145-4-PBS bindet in WB, IHC, IF/ICC, IF-P, Indirect ELISA PAX8 und zeigt Reaktivität mit human, Maus, Ratten
Getestete Reaktivität | human, Maus, Ratte |
Wirt / Isotyp | Maus / IgG2b |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | PAX8 fusion protein Ag0306 |
Vollständiger Name | paired box 8 |
Berechnetes Molekulargewicht | 48 kDa |
Beobachtetes Molekulargewicht | 48 kDa |
GenBank-Zugangsnummer | BC001060 |
Gene symbol | PAX8 |
Gene ID (NCBI) | 7849 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas.
PAX8 has 5 isoforms with calculated MW 31kd, 34kd, 41kd, 43kd and 48kd. And there is a 60kd band corresponding to the electrophoretic mobility of PAX8 (PMID:15650356).