PD-L2/CD273 Rekombinanter Antikörper

PD-L2/CD273 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241728D8

Kat-Nr. : 98241-1-PBS

Synonyme

CD273, Butyrophilin B7-DC, Btdc, B7-DC, B7dc

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  FC experiment of mouse splenocytes using 98241-1-RR (same clone as 98241-1-PBS)

  1x10^6 untreated or GM-CSF treated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse PD-L2/CD273 Rabbit Recombinant Antibody (98241-1-RR, Clone: 241728D8) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Mouse CD11c (N418) (APC-65130, Clone: N418). Cells were not fixed. This data was developed using the same antibody clone with 98241-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse splenocytes using 98241-1-RR (same clone as 98241-1-PBS)

  1x10^6 GM-CSF treated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse PD-L2/CD273 Rabbit Recombinant Antibody (98241-1-RR, Clone:241728D8) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse PD-L2/CD273 Rabbit Recombinant Antibody (98241-1-RR, Clone:241728D8) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98241-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98241-1-PBS bindet in FC PD-L2/CD273 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: programmed cell death 1 ligand 2
• Berechnetes Molekulargewicht: 28kDa
• GenBank-Zugangsnummer: NM_021396.2
• Gene symbol: Pdcd1lg2
• Gene ID (NCBI): 58205
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

Programmed cell death ligand 2 (PD-L2, also known as CD273, or B7-DC), is one of the B7 family molecules which are type I transmembrane proteins belonging to the immunoglobulin superfamily. PD-L2 was identified both by its homology to PD-L1 and by analysis of genes differentially expressed in libraries generated from dendritic cells (DC) and activated macrophages (PMID: 14515254). PD-L2 is a second ligand for PD-1, a costimulatory molecule that plays an inhibitory role in regulating T cell activation in the periphery.