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PDCD11 Polyklonaler Antikörper

PDCD11 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 31405-1-PBS

Synonyme

programmed cell death 11, NFBP, NF kappa B binding protein, KIAA0185, ALG4

Filter:
  • Western Blot (WB) analysis of various lysates using PDCD11 Polyclonal antibody (31405-1-AP)

    WB analysis using 31405-1-AP (same clone as 31405-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31405-1-AP (PDCD11 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31405-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

31405-1-PBS bindet in WB, Indirect ELISA PDCD11 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen PDCD11 fusion protein Ag35402
Vollständiger Name programmed cell death 11
Beobachtetes Molekulargewicht 209 kDa
GenBank-ZugangsnummerBC049838
Gene symbol PDCD11
Gene ID (NCBI) 22984
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PDCD11, also known as ALG-4, RRP5, or NFBP, possesses a series of S1 RNA-binding domains in the N-terminus with approximately 1,400 amino acids, followed by a tetratricopeptide repeat (TPR) domain in the C-terminus. Through S1 N-terminal domains, PDCD11 interacts with pre-rRNA to coordinate rRNA processing and assembly in the nucleolus. It also binds to Exonuclease-1 and upregulates Fas to induce cell apoptosis. Recently, PDCD11 was proved to interact with NF-κB subunits to suppress the expression of inflammatory cytokines and activate the TGFβ1 pathway, thereby modulating microglia differentiation during zebrafish development.(PMID: 38062028)