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PDE4C Polyklonaler Antikörper

PDE4C Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 21754-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of HEK-293 cells using PDE4C Polyclonal antibody (21754-1-AP)

    WB analysis of HEK-293 using 21754-1-AP (same clone as 21754-1-PBS)

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 21754-1-AP (PDE4C antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21754-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of mouse lung tissue using PDE4C Polyclonal antibody (21754-1-AP)

    WB analysis of mouse lung using 21754-1-AP (same clone as 21754-1-PBS)

    mouse lung tissue were subjected to SDS PAGE followed by western blot with 21754-1-AP (PDE4C antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21754-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

21754-1-PBS bindet in WB, Indirect ELISA PDE4C und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen PDE4C fusion protein Ag16130
Vollständiger Name phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
Berechnetes Molekulargewicht 712 aa, 80 kDa
Beobachtetes Molekulargewicht~70 kDa
GenBank-ZugangsnummerBC109067
Gene symbol PDE4C
Gene ID (NCBI) 5143
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PDE4C(cAMP-specific 3,5-cyclic phosphodiesterase 4C) is also named as DPDE1 and belongs to the PDE4 subfamily, which play a key role in lung inflammation and hyperresponsiveness. PDE4C promotes the hydrolysis of cAMP, and PKD2, functioning as a Ca2+ entry channel, may mediate local accumulation of Ca2+ that inhibits the activity of Ca2+-sensitive ADCY5(PMID:21670265). The three isoforms(84,75, and 64 kDa) of PDE4C have been detected in cytosolic, microsomal, and nuclear (PMID:21784969).