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PGRMC1 Monoklonaler Antikörper

PGRMC1 Monoklonal Antikörper für IF

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

Hausschwein, human, Maus, Ratte

Anwendung

IF

Konjugation

CoraLite®594 Fluorescent Dye

CloneNo.

1C10D11

Kat-Nr. : CL594-66372

Synonyme

HPR6.6, MPR, PGRMC, PGRMC1

Galerie der Validierungsdaten

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  • Immunofluorescence (IF) / fluorescent staining of human ovary tumor tissue using CoraLite®594-conjugated PGRMC1 Monoclonal antibody (CL594-66372)

    IF Staining of human ovary tumor using CL594-66372

    Immunofluorescent analysis of (4% PFA) fixed human ovary tumor tissue using CoraLite®594 PGRMC1 antibody (CL594-66372, Clone: 1C10D11 ) at dilution of 1:200.

  • Immunofluorescence (IF) / fluorescent staining of human ovary tumor tissue using CoraLite®594-conjugated PGRMC1 Monoclonal antibody (CL594-66372)

    IF Staining of human ovary tumor using CL594-66372

    Immunofluorescent analysis of (4% PFA) fixed human ovary tumor tissue using CoraLite®594 PGRMC1 antibody (CL594-66372, Clone: 1C10D11 ) at dilution of 1:200.

Geprüfte Anwendungen

Erfolgreiche Detektion in IFhumanes Ovarialkarzinomgewebe

Empfohlene Verdünnung

AnwendungVerdünnung
Immunfluoreszenz (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

CL594-66372 bindet in IF PGRMC1 und zeigt Reaktivität mit Hausschwein, human, Maus, Ratten

Getestete Reaktivität Hausschwein, human, Maus, Ratte
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen PGRMC1 fusion protein Ag3643
Vollständiger Name progesterone receptor membrane component 1
Berechnetes Molekulargewicht 195 aa, 22 kDa
Beobachtetes Molekulargewicht 25-27 kDa
GenBank-ZugangsnummerBC034238
Gene symbol PGRMC1
Gene ID (NCBI) 10857
Konjugation CoraLite®594 Fluorescent Dye
Excitation/Emission maxima wavelengths588 nm / 604 nm
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer BS mit 50% Glyzerin, 0,05% Proclin300, 0,5% BSA, pH 7,3.
LagerungsbedingungenBei -20°C lagern. Vor Licht schützen. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Progesterone receptor membrane component 1 (PGRMC1) is a member of a multi-protein progesterone-binding complex. However, PGRMC1 shares homology with cytochrome b5-related proteins rather than hormone receptors (PMID: 18992768). It is a heme binding protein with biding sites for Src homology (SH2) and SH3 domain-containing proteins (PMID: 17583495). PGRMC1 is overexpressed in a variety of cancers, and thus represents an important biomarker for cancer progression and a potential target for anticancer drugs (PMID: 21730960). In nonmalignant tissues, PGRMC1 is highly expressed in the liver and kidney (PMID: 9705155; 20164297).

Protokolle

Produktspezifische Protokolle
IF protocol for CL594 PGRMC1 antibody CL594-66372Protokoll herunterladen
Standard-Protokolle
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen