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PICK1 Monoklonaler Antikörper

PICK1 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

Hausschwein, human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2E11A4

Kat-Nr. : 67099-1-PBS

Synonyme

PICK, PICK1, PRKCA binding protein, PRKCABP

Filter:
  • Western Blot (WB) analysis of various lysates using PICK1 Monoclonal antibody (67099-1-Ig)

    WB analysis using 67099-1-Ig (same clone as 67099-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67099-1-Ig (PICK1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67099-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

67099-1-PBS bindet in WB, Indirect ELISA PICK1 und zeigt Reaktivität mit Hausschwein, human, Maus, Ratten

Getestete Reaktivität Hausschwein, human, Maus, Ratte
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen PICK1 fusion protein Ag28609
Vollständiger Name protein interacting with PRKCA 1
Berechnetes Molekulargewicht 47 kDa
Beobachtetes Molekulargewicht 50 kDa
GenBank-ZugangsnummerBC017561
Gene symbol PICK1
Gene ID (NCBI) 9463
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Protein interacting with C kinase 1 (PICK1) was first cloned as a PKC-binding partner through yeast two hybrid system. PICK1 acts as a critical regulator of membrane receptors' subcellular trafficking to modulate neural processes such as learning and memory, and is widely expressed in brain, testis, heart, lung, liver, kidney and muscle. It probably binds to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence, for instance, PICK1 is a critical mediator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking in neural synapses. PICK1 expression on D-serine release and glutamate transport in astrocytes suggests a potential implication of PICK1 in the progression of amyotrophic lateral sclerosis (ALS). PICK1 may also participate in breast cancer development through inhibition of TGF-β signaling.