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- KD/KO Validated
PKC Iota Monoklonaler Antikörper
PKC Iota Monoklonal Antikörper für
Wirt / Isotyp
Maus / IgG2a
Getestete Reaktivität
human, Maus, Ratte
Anwendung
Konjugation
CoraLite® Plus 647 Fluorescent Dye
CloneNo.
3A1B6
Kat-Nr. : CL647-66493
Synonyme
Geprüfte Anwendungen
Produktinformation
CL647-66493 bindet in PKC Iota und zeigt Reaktivität mit human, Maus, Ratten
| Getestete Reaktivität | human, Maus, Ratte |
| Wirt / Isotyp | Maus / IgG2a |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | PKC Iota fusion protein Ag4990 |
| Vollständiger Name | protein kinase C, iota |
| Berechnetes Molekulargewicht | 68 kDa |
| Beobachtetes Molekulargewicht | 70 kDa |
| GenBank-Zugangsnummer | BC022016 |
| Gene symbol | PKC Iota |
| Gene ID (NCBI) | 5584 |
| Konjugation | CoraLite® Plus 647 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 654 nm / 674 nm |
| Form | Liquid |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA |
| Lagerungsbedingungen | Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
The atypical protein kinase C isoform PRKC iota (PRKCI) is a member of the protein kinase C (PKC) family of serine/threonine protein kinases. PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. PRKC iota is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. PRKC iota plays a key role in cell proliferation, differentiation, and carcinogenesis, and it has been shown to be a human oncogene.
