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Plakophilin 1 Polyklonaler Antikörper

Plakophilin 1 Polyklonal Antikörper für WB, IHC, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 22632-1-PBS

Synonyme

PKP1, Plakophilin-1, B6P

Filter:
  • Western Blot (WB) analysis of various lysates using Plakophilin 1 Polyclonal antibody (22632-1-AP)

    WB analysis using 22632-1-AP (same clone as 22632-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22632-1-AP (PKP1 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22632-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human skin cancer tissue using Plakophilin 1 Polyclonal antibody (22632-1-AP)

    IHC staining of human skin cancer using 22632-1-AP (same clone as 22632-1-PBS)

    Immunohistochemical analysis of paraffin-embedded skin cancer slide using 22632-1-AP (PKP1 antibody) at dilution of 1:1200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22632-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of PC-3 cells using Plakophilin 1 Polyclonal antibody (22632-1-AP)

    IF Staining of PC-3 using 22632-1-AP (same clone as 22632-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed PC-3 cells using PKP1 antibody (22632-1-AP) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). This data was developed using the same antibody clone with 22632-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

22632-1-PBS bindet in WB, IHC, IF/ICC, Indirect ELISA Plakophilin 1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Plakophilin 1 fusion protein Ag18153
Vollständiger Name plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
Berechnetes Molekulargewicht 747 aa, 83 kDa
Beobachtetes Molekulargewicht70-75 kDa
GenBank-ZugangsnummerBC114571
Gene symbol PKP1
Gene ID (NCBI) 5317
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Plakophilin 1, also known as PKP1, B6P, is a member of the arm-repeat protein family. PKP1 contains arm-repeat (armadillo) domains, localizes to nuclei and cell desmosomes, and participates in linking cadherins to intermediate filaments in the cytoskeleton (PMID: 10747098). PKP1 contributes to epidermal morphogenesis and facilitates the formation of intermediate filaments. Mutations in PKP1 have been associated with the ectodermal dysplasia/skin fragility syndrome (PubMed:9326952, 10852826).