PLA2R1 Polyklonaler Antikörper
PLA2R1 Polyklonal Antikörper für ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
ELISA
Konjugation
Unkonjugiert
Kat-Nr. : 25695-1-AP
Synonyme
Galerie der Validierungsdaten
Geprüfte Anwendungen
Empfohlene Verdünnung
| Anwendung | Verdünnung |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Produktinformation
25695-1-AP bindet in ELISA PLA2R1 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Polyklonal |
| Typ | Antikörper |
| Immunogen | PLA2R1 fusion protein Ag22448 |
| Vollständiger Name | phospholipase A2 receptor 1, 180kDa |
| Berechnetes Molekulargewicht | 1463 aa, 169 kDa |
| GenBank-Zugangsnummer | BC140823 |
| Gene symbol | PLA2R1 |
| Gene ID (NCBI) | 22925 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Antigen-Affinitätsreinigung |
| Lagerungspuffer | PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3. |
| Lagerungsbedingungen | Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Secretory phospholipase A2 (sPLA2) are implicated in a number of crucial physiological and pathological processes in mammals. Different types of membrane receptors for sPLA2s have been identified. The M-type receptor, PLA2R1 (phospholipase A2 receptor 1, 180 kDa), is a type I transmembrane glycoprotein containing extracellularly a cysteine-rich domain, a fibronectin type II domain and eight carbohydrate-recognition domains. It is a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. It is also able to bind to snake PA2-like toxins. PLA2R1 may be involved in responses in proinflammatory cytokine productions during endotoxic shock. It also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. It has been recently shown that PLA2R1 is the major target antigen in idiopathic membranous nephropathy (iMN). Patients with iMN have antibodies against a conformation-dependent epitope in PLA2R1.
