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PMS1 Monoklonaler Antikörper

PMS1 Monoklonal Antikörper für WB, IF/ICC, ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, ELISA

Konjugation

Unkonjugiert

CloneNo.

1A6G3

Kat-Nr. : 68413-1-PBS

Synonyme

DKFZp781M0253, FLJ98259, HNPCC3, hPMS1, PMS1, PMS1 protein homolog 1, PMSL1

Filter:
  • Western Blot (WB) analysis of various lysates using PMS1 Monoclonal antibody (68413-1-Ig)

    WB analysis using 68413-1-Ig (same clone as 68413-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68413-1-Ig (PMS1 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68413-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of Caco-2 cells using PMS1 Monoclonal antibody (68413-1-Ig)

    IF Staining of Caco-2 using 68413-1-Ig (same clone as 68413-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed Caco-2 cells using PMS1 antibody (68413-1-Ig, Clone: 1A6G3 ) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 68413-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68413-1-PBS bindet in WB, IF/ICC, ELISA PMS1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen PMS1 fusion protein Ag28127
Vollständiger Name PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
Beobachtetes Molekulargewicht 106 kDa
GenBank-ZugangsnummerBC096331
Gene symbol PMS1
Gene ID (NCBI) 5378
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PMS1 Homolog 1 is a member of the DNA mismatch repair enzymes (MMREs) which is to eliminate the mismatch of insertions and deletions as a consequence of DNA polymerase errors at DNA synthesis in eukaryotes. PMS1 and MLH1 could form a heterodimer MutLβ that belongs to MMREs (PMID:25619773). In the MMR system, the MutS complex recognizes the DNA mispairs firstly, and then the Mlh1-Pms1 and other associated proteins such as PCNA, RFC, ExoI were recruited, inducing Exonuclease 1 (Exo1)-dependent and -independent MMR pathways (PMID:24981171). Mutations in this gene cause hereditary nonpolyposis colorectal cancer(HNPCC), which is also known as Lynch syndrome. It was reported that PMS1 is a widely expressed protein and located in the nucleus. Alternative splicing allows for 4 isoforms of PMS1 protein.