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PMS2 Monoklonaler Antikörper

PMS2 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1G4E6

Kat-Nr. : 66075-1-PBS

Synonyme

1G4E6, EC:3.1.-.-, HNPCC4, PMS1 protein homolog 2, PMS2CL

Filter:
  • Western Blot (WB) analysis of HeLa cells using PMS2 Monoclonal antibody (66075-1-Ig)

    WB analysis of HeLa using 66075-1-Ig (same clone as 66075-1-PBS)

    Vairous cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of A431 cells using PMS2 Monoclonal antibody (66075-1-Ig)

    WB analysis of A431 using 66075-1-Ig (same clone as 66075-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HeLa cells using PMS2 Monoclonal antibody (66075-1-Ig)

    WB analysis of HeLa using 66075-1-Ig (same clone as 66075-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

66075-1-PBS bindet in WB, Indirect ELISA PMS2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen PMS2 fusion protein Ag12661
Vollständiger Name PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
Berechnetes Molekulargewicht 862 aa, 96 kDa
Beobachtetes Molekulargewicht 100 kDa
GenBank-ZugangsnummerBC093921
Gene symbol PMS2
Gene ID (NCBI) 5395
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PMS2, also named as PMSL2, belongs to the DNA mismatch repair mutL/hexB family. It is a component of the post-replicative DNA mismatch repair system (MMR). It heterodimerizes with MLH1 to form MutL alpha. MulL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. It also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. (PMID: 16873062, PMID: 18206974) Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS).