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PNMT Rekombinanter Antikörper

PNMT Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241111G1

Kat-Nr. : 83979-5-PBS

Synonyme

241111G1, EC:2.1.1.28, Noradrenaline N-methyltransferase, PENT, Phenylethanolamine N-methyltransferase

Filter:
  • Western Blot (WB) analysis of K-562 cells using PNMT Recombinant antibody (83979-5-RR)

    WB analysis of K-562 using 83979-5-RR (same clone as 83979-5-PBS)

    K-562 cells were subjected to SDS PAGE followed by western blot with 83979-5-RR (PNMT antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83979-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83979-5-RR

    Affinity and Kinetic Characterization of 83979-5-RR

    Biolayer interferometry (BLl) kinetic assays of 83979-5-RR against Human PNMT were performed. The affinity constant is 8.83 pM.

Geprüfte Anwendungen

Produktinformation

83979-5-PBS bindet in WB, Indirect ELISA PNMT und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen PNMT fusion protein Ag4098
Vollständiger Name phenylethanolamine N-methyltransferase
Berechnetes Molekulargewicht 282 aa, 31 kDa
Beobachtetes Molekulargewicht31 kDa
GenBank-ZugangsnummerBC037246
Gene symbol PNMT
Gene ID (NCBI) 5409
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PNMT (Phenylethanolamine N-methyltransferase) is the final enzyme in the catecholamine synthesizing cascade that converts noradrenaline to epinephrine by transferring a methyl group from S-adenosyl-L-methionine (SAM) to norepinephrine. PNMT is primarily found in the adrenal medulla, where it is responsible for the production of epinephrine. It is also present in certain areas of the brain, such as the amygdala and retina, where it may be involved in various neurophysiological functions (PMID: 17175506). Variations in the PNMT gene have been associated with Alzheimer's disease, hypertension, and other disorders (PMID: 2816488,.11514309).