PNRC2 Polyklonaler Antikörper
PNRC2 Polyklonal Antikörper für Indirect ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human, Maus
Anwendung
Indirect ELISA
Konjugation
Unkonjugiert
Kat-Nr. : 51050-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
51050-1-PBS bindet in Indirect ELISA PNRC2 und zeigt Reaktivität mit human, Maus
| Getestete Reaktivität | human, Maus |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Polyklonal |
| Typ | Antikörper |
| Immunogen | PNRC2 fusion protein Ag0099 |
| Vollständiger Name | proline-rich nuclear receptor coactivator 2 |
| Berechnetes Molekulargewicht | 16 kDa |
| Beobachtetes Molekulargewicht | 25 kDa |
| GenBank-Zugangsnummer | BC001959 |
| Gene symbol | PNRC2 |
| Gene ID (NCBI) | 55629 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Antigen-Affinitätsreinigung |
| Lagerungspuffer | PBS only |
| Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
PNRC2 belongs to the PNRC family and PNRC2 subfamily. It is Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. It is required for UPF1/RENT1 localization to the P-body. PNRC2 also acts as a nuclear receptor coactivator. It may play a role in controlling the energy balance between energy storage and energy expenditure. (PMID:19150429) PNRC2 functions as a coactivator of several nuclear receptors, including ERRa, and participates in the activation of aromatase in conjunction with ERRa. Growth factor signaling promotes PELP1 recruitment to the aromatase chromatin and its formation of a complex with ERRa and PNRC2.(PMID:18079323)
