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PON1 Rekombinanter Antikörper

PON1 Rekombinant Antikörper für WB, Cytometric bead array, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Cytometric bead array, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241091B7

Kat-Nr. : 83982-2-PBS

Synonyme

241091B7, A-esterase 1, Aromatic esterase 1, EC:3.1.1.2, K-45

Filter:
  • Western Blot (WB) analysis of various lysates using PON1 Recombinant antibody (83982-2-RR)

    WB analysis using 83982-2-RR (same clone as 83982-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83982-2-RR (PON1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83982-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83982-2-RR

    Affinity and Kinetic Characterization of 83982-2-RR

    Biolayer interferometry (BLl) kinetic assays of 83982-2-RR against Human PON1 were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

83982-2-PBS bindet in WB, Cytometric bead array, Indirect ELISA PON1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen PON1 fusion protein Ag12934
Vollständiger Name paraoxonase 1
Berechnetes Molekulargewicht 355 aa, 40 kDa
Beobachtetes Molekulargewicht40-45 kDa
GenBank-ZugangsnummerBC074719
Gene symbol PON1
Gene ID (NCBI) 5444
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PON1, also named PON and K-45, belongs to the paraoxonase family. PON1 hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. It is capable of hydrolyzing a broad spectrum of organophosphate substrates and several aromatic carboxylic acid esters. PON1 may mediate enzymatic protection of low-density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. PON1 was identified as a triple band in a range of approximately 35-40 kDa. For glycosylated, the MW of PON1 is migrated 42-45kd, while the 35 kDa band represents the unglycosylated form (PMID: 17906223, 32002976, 21852972). The antibody has cross-reaction to PON2 and PON3.