PON3 Polyklonaler Antikörper

PON3 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 31793-1-PBS

Synonyme

Paraoxonase 3 , Paraoxanase-3, EC:3.1.8.1

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  WB analysis using 31793-1-AP (same clone as 31793-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31793-1-AP (PON3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

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  IHC staining of rat liver using 31793-1-AP (same clone as 31793-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat liver tissue slide using 31793-1-AP (PON3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

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  IHC staining of rat liver using 31793-1-AP (same clone as 31793-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat liver tissue slide using 31793-1-AP (PON3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse liver using 31793-1-AP (same clone as 31793-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 31793-1-AP (PON3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse liver using 31793-1-AP (same clone as 31793-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 31793-1-AP (PON3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 31793-1-AP (same clone as 31793-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 31793-1-AP (PON3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 31793-1-AP (same clone as 31793-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 31793-1-AP (PON3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

31793-1-PBS bindet in WB, IHC, Indirect ELISA PON3 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: PON3 fusion protein Ag36602
• Vollständiger Name: paraoxonase 3
• Berechnetes Molekulargewicht: NM_000940.2 40kDa，354aa
• Beobachtetes Molekulargewicht: 40 kDa
• GenBank-Zugangsnummer: NM_000940.2
• Gene symbol: PON3
• Gene ID (NCBI): 5446
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PON3, a member of the paraoxonase family, is expressed primarily in the liver and encodes a protein that is secreted into the bloodstream and binds to high-density lipoprotein (HDL). It also rapidly hydrolyzes lactones and inhibits the oxidation of low-density lipoprotein (LDL), thereby slowing the onset and progression of atherosclerosis. In addition, PON3 is closely associated with hepatocellular carcinoma (HCC), and is a potential therapeutic target for HCC by inducing cell cycle arrest and further inhibiting HCC cell proliferation.