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- KD/KO Validated
PGC1a Polyklonaler Antikörper
PGC1a Polyklonal Antikörper für ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human, Maus und mehr (4)
Anwendung
WB, IHC, IF, chIP, ELISA
Konjugation
Unkonjugiert
Kat-Nr. : 20658-1-AP
Synonyme
Galerie der Validierungsdaten
Geprüfte Anwendungen
Empfohlene Verdünnung
| Anwendung | Verdünnung |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Veröffentlichte Anwendungen
| KD/KO | See 2 publications below |
| WB | See 42 publications below |
| IHC | See 8 publications below |
| IF | See 5 publications below |
| ChIP | See 1 publications below |
Produktinformation
20658-1-AP bindet in WB, IHC, IF, chIP, ELISA PGC1a und zeigt Reaktivität mit human, Maus
| Getestete Reaktivität | human, Maus |
| In Publikationen genannte Reaktivität | human, Huhn, Maus, Ratte, Zebrafisch, Ziege |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Polyklonal |
| Typ | Antikörper |
| Immunogen | Peptid |
| Vollständiger Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
| Berechnetes Molekulargewicht | 91 kDa |
| Beobachtetes Molekulargewicht | 91-98 kDa |
| GenBank-Zugangsnummer | NM_013261 |
| Gene symbol | PPARGC1A |
| Gene ID (NCBI) | 10891 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Antigen-Affinitätsreinigung |
| Lagerungspuffer | PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3. |
| Lagerungsbedingungen | Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
PPARGC1A, also named as Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, is a 798 amino acid protein, which Contains 1 RRM (RNA recognition motif) domain and localizes in the nucleus. PPARGC1A is transcriptional coactivator for steroid receptors and nuclear receptors. PPARGC1A can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis and plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. PPARGC1A exists various isoforms and range of molecular weight of isoforms are 30-50 kDa and 90-110 kDa.
Publikationen
| Species | Application | Title |
|---|---|---|
Redox Biol Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy. | ||
Autophagy FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway. | ||
Part Fibre Toxicol Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role of mitochondria. | ||
Oxid Med Cell Longev Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy. | ||
Redox Biol Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro. |
