Progesterone Receptor Monoklonaler Antikörper

Progesterone Receptor Monoklonal Antikörper für IHC

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

IHC

Konjugation

Biotin

CloneNo.

3D1D12

Kat-Nr. : Biotin-66300

Synonyme

PGR, PRGR, PR, NR3C3, 3D1D12

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  IHC staining of human breast cancer using Biotin-66300

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using Biotin-66300 (PR antibody) at dilution of 1:1000 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human ovary tumor using Biotin-66300

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using Biotin-66300 (Progesterone Receptor antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human breast cancer using Biotin-66300

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using Biotin-66300 (PR antibody) at dilution of 1:1000 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IHC: humanes Ovarialkarzinomgewebe, humanes Mammakarzinomgewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Immunhistochemie (IHC): IHC : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

Biotin-66300 bindet in IHC Progesterone Receptor und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Progesterone Receptor fusion protein Ag22992
• Vollständiger Name: progesterone receptor
• Berechnetes Molekulargewicht: 933 aa, 99 kDa
• GenBank-Zugangsnummer: NM_000926
• Gene symbol: Progesterone Receptor
• Gene ID (NCBI): 5241
• Konjugation: Biotin
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA
• Lagerungsbedingungen: Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PGR (Progesterone Receptor), also named as NR3C3 and PR, belongs to the nuclear hormone receptor family and NR3 subfamily. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. The ER and PR status has been used as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.