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PRDX1 Rekombinanter Antikörper

PRDX1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251425E8

Kat-Nr. : 86589-1-PBS

Synonyme

EC:1.11.1.24, MSP23, Natural killer cell-enhancing factor A, NKEF-A, PAG

Filter:
  • Western Blot (WB) analysis of various lysates using PRDX1 Recombinant monoclonal antibody (86589-1-RR)

    WB analysis using 86589-1-RR (same clone as 86589-1-PBS)

    K-562 cells were subjected to SDS PAGE followed by western blot with 86589-1-RR (PRDX1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86589-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86589-1-PBS bindet in WB, Indirect ELISA PRDX1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen PRDX1 fusion protein Ag8602
Vollständiger Name peroxiredoxin 1
Berechnetes Molekulargewicht 199 aa, 22 kDa
Beobachtetes Molekulargewicht 23 kDa
GenBank-ZugangsnummerBC007063
Gene symbol PRDX1
Gene ID (NCBI) 5052
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PRDX1 (Peroxiredoxin-1), also named as PAGA, PAGB, TDPX2, PAG or NKEF-A, belongs to the ahpC/TSA family. PRDX1 is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2 (PMID: 9497357). It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. PRDX1 can form a dimer, and also can be phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity (PMID: 22583657, 11986303).