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PREX1 Polyklonaler Antikörper

PREX1 Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33193-1-PBS

Synonyme

KIAA1415, P REX1, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, P-Rex1, PtdIns(3,4,5)-dependent Rac exchanger 1

Filter:
  • Western Blot (WB) analysis of various lysates using PREX1 Polyclonal antibody (33193-1-AP)

    WB analysis using 33193-1-AP (same clone as 33193-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33193-1-AP (PREX1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33193-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of MCF-7 cells using PREX1 Polyclonal antibody (33193-1-AP)

    IF Staining of MCF-7 using 33193-1-AP (same clone as 33193-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed MCF-7 cells using PREX1 antibody (33193-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 33193-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

33193-1-PBS bindet in WB, IF/ICC, Indirect ELISA PREX1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen PREX1 fusion protein Ag36649
Vollständiger Name phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Berechnetes Molekulargewicht186 kDa
Beobachtetes Molekulargewicht186 kDa
GenBank-ZugangsnummerNM_020820.3
Gene symbol PREX1
Gene ID (NCBI) 57580
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1) is a guanine nucleotide exchange factor (GEF) that specifically activates Rac GTPases, particularly Rac1 (PMID: 16243035). PREX1 is activated downstream of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs), such as ErbB receptors, and is involved in PI3K/AKT and MAPK signaling pathways (PMID: 28710285; 27358402). It contributes to glucose uptake in adipocytes and promotes tumor cell proliferation, migration, and metastasis in various cancers, including breast, prostate, and melanoma (PMID: 22109529).