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PRSS8 Polyklonaler Antikörper

PRSS8 Polyklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 15527-1-PBS

Synonyme

CAP1, Channel-activating protease 1, EC:3.4.21.-, Prostasin heavy chain, Prostasin light chain

Filter:
  • Western Blot (WB) analysis of mouse kidney tissue using PRSS8 Polyclonal antibody (15527-1-AP)

    WB analysis of mouse kidney using 15527-1-AP (same clone as 15527-1-PBS)

    mouse kidney tissue were subjected to SDS PAGE followed by western blot with 15527-1-AP (PRSS8 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15527-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse ovary tissue using PRSS8 Polyclonal antibody (15527-1-AP)

    IHC staining of mouse ovary using 15527-1-AP (same clone as 15527-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse ovary tissue slide using 15527-1-AP (PRSS8 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15527-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human ovary tumor tissue using PRSS8 Polyclonal antibody (15527-1-AP)

    IHC staining of human ovary tumor using 15527-1-AP (same clone as 15527-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 15527-1-AP (PRSS8 Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 15527-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human ovary tumor tissue using PRSS8 Polyclonal antibody (15527-1-AP)

    IHC staining of human ovary tumor using 15527-1-AP (same clone as 15527-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 15527-1-AP (PRSS8 Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 15527-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

15527-1-PBS bindet in IHC, Indirect ELISA PRSS8 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen PRSS8 fusion protein Ag7234
Vollständiger Name protease, serine, 8
Berechnetes Molekulargewicht 36 kDa
Beobachtetes Molekulargewicht 39 kDa
GenBank-ZugangsnummerBC001462
Gene symbol PRSS8
Gene ID (NCBI) 5652
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Protease serine S1 family member 8 (PRSS8), a membrane-anchored serine protease, has been reported to be involved in the development of several human cancers. PRSS8 protein level was highly expressed in well differentiated cancer cell and was lower or absent in poorly differentiated cancer cell. Significantly higher levels of prostasin were found in early stage OVC serum samples compared to benign ovarian and normal donor samples. Overexpression of PRSS8 mRNA and high levels of prostasin in multiple subtypes of early stage ovarian tumors may provide clinical biomarkers for early detection of OVC. (PMID: 27036110, PMID: 27050145)