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PRUNE2 Polyklonaler Antikörper

PRUNE2 Polyklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 11458-1-PBS

Synonyme

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  • Immunohistochemistry (IHC) staining of human liver cancer tissue using PRUNE2 Polyclonal antibody (11458-1-AP)

    IHC staining of human liver cancer using 11458-1-AP (same clone as 11458-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 11458-1-AP (PRUNE2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11458-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

11458-1-PBS bindet in IHC, Indirect ELISA PRUNE2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen PRUNE2 fusion protein Ag2025
Vollständiger Name prune homolog 2 (Drosophila)
Berechnetes Molekulargewicht 341 kDa
Beobachtetes Molekulargewicht 140~150 kDa
GenBank-ZugangsnummerBC019095
Gene symbol PRUNE2
Gene ID (NCBI) 158471
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PRUNE2 gene, also named BMCC1, encodes protein prune homolog 2. PRUNE2 gene are overlapping with PCA3, one of the most prostate cancer specific markers. PRUNE2 may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. Besides its high level of expression seen in the nervous system (brain, cerebellum and spinal cord), it is also expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in cancer cell lines of liver, breast, thyroid and colon. The Calculated molecular weight of this protein is 340 kDa. Our antibody specifically recognises the 140-150 kDa band which is an isoform or cleaved fragment of PRUNE2 (PMID:21234814).