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PSAP Rekombinanter Antikörper

PSAP Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250312B12

Kat-Nr. : 86043-3-PBS

Synonyme

Prosaposin, Saposin-A, Saposin-B, Saposin-B-Val, Saposin-C

Filter:
  • Western Blot (WB) analysis of various lysates using PSAP Recombinant antibody (86043-3-RR)

    WB analysis using 86043-3-RR (same clone as 86043-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86043-3-RR (Psap antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86043-3-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86043-3-PBS bindet in WB, Indirect ELISA PSAP und zeigt Reaktivität mit Maus, Ratten

Getestete Reaktivität Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen PSAP fusion protein Eg3155
Vollständiger Name prosaposin
Berechnetes Molekulargewicht61 kDa
Beobachtetes Molekulargewicht 65-70 kDa
GenBank-ZugangsnummerNM_011179.3
Gene symbol Psap
Gene ID (NCBI) 19156
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Prosaposin (PSAP) is also named as Sulfated glycoprotein 1 (SGP-1). PSAP is a secreted neurotrophic factor and a lysosomal protein serving as the precursor of saposins (A-D), which are cofactors for hydrolases of sphingolipids (PMID: 25130661, PMID: 31220974). PSAP modulates glycosphingolipid metabolism and variants have been linked to Parkinson's disease (PD) (PMID: 37726325). As a dual-function protein, PSAP is a lysosome-associated protein that participates in a variety of cellular processes. In the lysosome, PSAP is processed to activate enzymes that degrade lipids. PSAP proteins located extracellularly are involved in cancer progression, such as proliferation and tumor death suppression signaling (PMID: 39405903). Prosaposin (PSAP) has two forms: a precursor and a secreted form. The secreted form has neurotrophic, myelinotrophic, and myotrophic properties. The precursor form is a precursor protein of saposins A-D (PMID: 33242172). Both human and mouse prosaposin are 65-70 kDa proteins cleaved in the lysosomes into four 10-15 kDa proteins designated saposins A, B, C and D (PMID: 8573994). Sulfated glycoprotein-1 (prosaposin) exists in 2 forms: a 65 kDa form targeted to lysosomes and a post-translationally modified to the 70 kDa form secreted extracellularly (PMID: 8593668).