Presenilin-1-Specific Rekombinanter Antikörper

Presenilin-1-Specific Rekombinant Antikörper für Cytometric bead array, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

Cytometric bead array, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

240615B3

Kat-Nr. : 83618-1-PBS

Synonyme

PSEN1-Specific, PSEN1, Presenilin-1 CTF12, Presenilin-1 CTF subunit, Presenilin-1

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  Cytometric bead array standard curve of MP00597-1

  Cytometric bead array standard curve of MP00597-1, Presenilin-1 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 83618-2-PBS. Detection antibody: 83618-1-PBS. Standard: SY00068. Range: 39-5000 pg/mL.

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Geprüfte Anwendungen

Produktinformation

83618-1-PBS bindet in Cytometric bead array, Indirect ELISA Presenilin-1-Specific und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: presenilin 1
• Berechnetes Molekulargewicht: 53 kDa
• GenBank-Zugangsnummer: NM_000021
• Gene symbol: PSEN1
• Gene ID (NCBI): 5663
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PSEN1(presenilin-1) is also named as AD3, PS1, PSNL1 and belongs to the peptidase A22A family. It directly influences Netrin/DCC signaling with cell type precision and spatiotemporal specificity, and is a key neural circuit builder that gates the spatiotemporal pattern of guidance signaling, thereby ensuring neural projections occur with high fidelity(PMID:21215373). The 46-kDa PSEN1 holoprotein is cleaved into a D30-kDa N-terminal fragment (NTF) and a D20-kDa C-terminal fragment (CTF) by the 26S proteasome (PMID:10527805). It has 7 isoforms produced by alternative splicing. This antibody is specific to isoform1(53 kDa), isoform2(52 kDa), isoform4(21 kDa), isoform7(49 kDa) of this protein.