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PSPC1 Rekombinanter Antikörper

PSPC1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242158G7

Kat-Nr. : 84657-4-PBS

Synonyme

PSPC 1, PSP1, 242158G7

Filter:
  • Western Blot (WB) analysis of various lysates using PSPC1 Recombinant antibody (84657-4-RR)

    WB analysis using 84657-4-RR (same clone as 84657-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84657-4-RR (PSPC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84657-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84657-4-RR

    Affinity and Kinetic Characterization of 84657-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84657-4-RR against Human PSPC1 were performed. The affinity constant is 0.68 nM.

Geprüfte Anwendungen

Produktinformation

84657-4-PBS bindet in WB, Indirect ELISA PSPC1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen PSPC1 fusion protein Ag10136
Vollständiger Name paraspeckle component 1
Berechnetes Molekulargewicht 523 aa, 59 kDa
Beobachtetes Molekulargewicht 66 kDa
GenBank-ZugangsnummerBC014184
Gene symbol PSPC1
Gene ID (NCBI) 55269
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PSPC1 (paraspeckle component 1), a known paraspeckle biomarker, is a putative transcription factor that belongs to the Drosophila behavior/human splicing (DBHS) family. PSPC1 was recently identified as a contextual determinant of tumor progression in multiple cancer types involving oncogenic reprogramming to switch proapoptotic TGF-β to prometastatic TGF-β via hijacking of Smad2/3 targeting. Upregulated PSPC1 is correlated with advanced tumor stages and poor survival of patients with breast, lung, and liver cancers. Upregulated PSPC1 potentiates expression of mesenchymal markers, EMT transcription factors (EMT-TF), cancer stem-like cell transcription factors (CSC-TF), and c-Myc-related proliferation genes, thus promoting migration, invasion, spheroid formation, tumor formation, and metastasis.