- Featured Product
- KD/KO Validated
PTBP1 Monoklonaler Antikörper
PTBP1 Monoklonal Antikörper für
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human, Maus, Ratte
Anwendung
Konjugation
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
3D6D8
Kat-Nr. : CL488-67462
Synonyme
Geprüfte Anwendungen
Produktinformation
CL488-67462 bindet in PTBP1 und zeigt Reaktivität mit human, Maus, Ratten
| Getestete Reaktivität | human, Maus, Ratte |
| Wirt / Isotyp | Maus / IgG1 |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | PTBP1 fusion protein Ag28404 |
| Vollständiger Name | polypyrimidine tract binding protein 1 |
| Berechnetes Molekulargewicht | 60 kDa |
| Beobachtetes Molekulargewicht | 60 kDa |
| GenBank-Zugangsnummer | BC013694 |
| Gene symbol | PTBP1 |
| Gene ID (NCBI) | 5725 |
| Konjugation | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Reinigungsmethode | Protein-G-Reinigung |
| Lagerungspuffer | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA |
| Lagerungsbedingungen | Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Polypyrimidine tract-binding protein (PTBP1), also known as heterogeneous nuclear ribonucleoprotein type I (hnRNP I), is a nuclear protein that binds pre-mRNAs in specific regions of the hnRNA-protein complexes sensitive to micrococcal nuclease. It involves in pre-mRNA splicing and the regulation of alternative splicing events. PTBP1 promotes RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA, and promotes the binding of U2 snRNP to pre-mRNA. Besides, it can cooperate with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA, and represses the splicing of MAPT/Tau exon 10.
