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PTCH2 Polyklonaler Antikörper

PTCH2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 55091-1-PBS

Synonyme

UNQ560/PRO1121/PRO57079, PTC2, Protein patched homolog 2, patched homolog 2 (Drosophila), Patched 2

Filter:
  • Western Blot (WB) analysis of HepG2 cells using PTCH2 Polyclonal antibody (55091-1-AP)

    WB analysis of HepG2 using 55091-1-AP (same clone as 55091-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 55091-1-AP (PTCH2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55091-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using PTCH2 Polyclonal antibody (55091-1-AP)

    WB analysis using 55091-1-AP (same clone as 55091-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 55091-1-AP (PTCH2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55091-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of human brain tissue using PTCH2 Polyclonal antibody (55091-1-AP)

    WB analysis of human brain using 55091-1-AP (same clone as 55091-1-PBS)

    human brain tissue were subjected to SDS PAGE followed by western blot with 55091-1-AP (PTCH2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55091-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

55091-1-PBS bindet in WB, Indirect ELISA PTCH2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name patched homolog 2 (Drosophila)
Berechnetes Molekulargewicht 131 kDa
Beobachtetes Molekulargewicht 131-140 kDa
GenBank-ZugangsnummerNM_003738
Gene symbol PTCH2
Gene ID (NCBI) 8643
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PTCH1 (patched homolog 1) and PTCH2 are twelve-pass transmembrane proteins that act receptors of Hedgehog signaling pathway (PMID: 8906794; 9811851). Signals of Hedgehog family proteins (SHH, IHH and DHH in humans) are transduced through Patched family receptors (PTCH1 and PTCH2) and Smoothened (SMO) to GLI family transcription factors. Hedgehog pathway plays a critical role in embryonic development and tissue homeostasis, and its dysregulation has been implicated in many human diseases including congenital disorder and cancer (PMID: 23719536; 23532857). PTCH2 may function as a tumor suppressor in the Hedgehog signaling pathway. Alterations in PTCH2 gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. This antibody is specific to PTCH2.