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PTPMT1 Polyklonaler Antikörper

PTPMT1 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 11493-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of mouse pancreas tissue using PTPMT1 Polyclonal antibody (11493-1-AP)

    WB analysis of mouse pancreas using 11493-1-AP (same clone as 11493-1-PBS)

    mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 11493-1-AP (PTPMT1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of rat pancreas tissue using PTPMT1 Polyclonal antibody (11493-1-AP)

    WB analysis of rat pancreas using 11493-1-AP (same clone as 11493-1-PBS)

    rat pancreas tissue were subjected to SDS PAGE followed by western blot with 11493-1-AP (PTPMT1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human pancreas cancer tissue using PTPMT1 Polyclonal antibody (11493-1-AP)

    IHC staining of human pancreas cancer using 11493-1-AP (same clone as 11493-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 11493-1-AP (PTPMT1 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

11493-1-PBS bindet in WB, IHC, Indirect ELISA PTPMT1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen PTPMT1 fusion protein Ag2063
Vollständiger Name protein tyrosine phosphatase, mitochondrial 1
Berechnetes Molekulargewicht 201 aa, 23 kDa
Beobachtetes Molekulargewicht 21-23 kDa
GenBank-ZugangsnummerBC020242
Gene symbol PTPMT1
Gene ID (NCBI) 114971
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Protein Tyrosine Phosphatase localized to the Mitochondrial 1 (PTPMT1) is a highly conserved, dual-specific phosphatase that resides on the matrix-facing side of the inner mitochondrial membrane (IMM). PTPMT1 is a mitochondrial phosphatase and a vital regulator of mitochondrial activities. Current work points to roles for PTPMT1 in the regulation of mitochondrial respiration, dynamics, and ultrastructure through the modulation of pyruvate importation, the tuning of TCA cycle activity, and the synthesis of cardiolipin. PTPMT1 is highly expressed in pancreatic b cells, whose mitochondria have the important function of coupling glucose metabolism to the secretion of insulin. (PMID: 16337125, PMID: 16061174, PMID: 33335799)