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PTPRH Monoklonaler Antikörper

PTPRH Monoklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

Hausschwein, human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

3C6E8

Kat-Nr. : 68635-1-PBS

Synonyme

3C6E8, R PTP H, SAP 1, SAP1

Filter:
  • Western Blot (WB) analysis of pig spleen tissue using PTPRH Monoclonal antibody (68635-1-Ig)

    WB analysis of pig spleen using 68635-1-Ig (same clone as 68635-1-PBS)

    pig spleen tissue were subjected to SDS PAGE followed by western blot with 68635-1-Ig (PTPRH antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68635-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of A431 cells using PTPRH Monoclonal antibody (68635-1-Ig)

    WB analysis of A431 using 68635-1-Ig (same clone as 68635-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 68635-1-Ig (PTPRH antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68635-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HT-29 cells using PTPRH Monoclonal antibody (68635-1-Ig)

    IF Staining of HT-29 using 68635-1-Ig (same clone as 68635-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HT-29 cells using PTPRH antibody (68635-1-Ig, Clone: 3C6E8 ) at dilution of 1:500 and Multi-rAb CoraLite® Plus 594-Goat Anti-Mouse Recombinant Secondary Antibody (H+L) (Cat.NO. RGAM004 ). This data was developed using the same antibody clone with 68635-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68635-1-PBS bindet in WB, IF/ICC, Indirect ELISA PTPRH und zeigt Reaktivität mit Hausschwein, human

Getestete Reaktivität Hausschwein, human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen PTPRH fusion protein Ag17351
Vollständiger Name protein tyrosine phosphatase, receptor type, H
Berechnetes Molekulargewicht 1115 aa, 122 kDa
Beobachtetes Molekulargewicht200-210 kDa
GenBank-ZugangsnummerBC111716
Gene symbol PTPRH
Gene ID (NCBI) 5794
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PTPRH, also known as SAP-1 (Stomach Cancer-Associated Protein-Tyrosine Phosphatase-1), is a member of the protein tyrosine phosphatase (PTP) family. These enzymes regulate cellular signaling by dephosphorylating tyrosine residues on proteins, counterbalancing kinase activity (PMID: 11278335). PTPRH is classified as a receptor-type PTP, characterized by an extracellular domain, a transmembrane region, and intracellular catalytic domains. In colorectal, gastric, and hepatocellular cancers, PTPRH is often upregulated and linked to poor prognosis (PMID: 12101188). Paradoxically, it may suppress tumorigenesis in other contexts by stabilizing cell adhesion. Overexpression in certain cancers suggests utility as a diagnostic or prognostic marker. The molecular weight of PTPRH is 122 kDa, it is reported that it can form a dimer with a molecular weight of 210 kDa (PMID:15850787).