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PTPRS Rekombinanter Antikörper

PTPRS Rekombinant Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

CloneNo.

241005B6

Kat-Nr. : 83833-5-PBS

Synonyme

Receptor-type tyrosine-protein phosphatase S, R PTP sigma, R PTP S, PTPSIGMA, EC:3.1.3.48

Filter:
  • Western Blot (WB) analysis of various lysates using PTPRS Recombinant antibody (83833-5-RR)

    WB analysis using 83833-5-RR (same clone as 83833-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83833-5-RR (rPTPσ antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83833-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83833-5-RR

    Affinity and Kinetic Characterization of 83833-5-RR

    Biolayer interferometry (BLl) kinetic assays of 83833-5-RR against Human PTPRS were performed. The affinity constant is 68.9 pM.

Geprüfte Anwendungen

Produktinformation

83833-5-PBS bindet in WB, ELISA PTPRS und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Fusionsprotein
Vollständiger Name protein tyrosine phosphatase, receptor type, S
Berechnetes Molekulargewicht217 kDa
Beobachtetes Molekulargewicht140 kDa, 217 kDa
GenBank-ZugangsnummerNM_002850
Gene symbol PTPRS
Gene ID (NCBI) 5802
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Protein tyrosine phosphatase receptor type S (PTPRS, also known as R-PTP-S, PTPSIGMA, and R-PTP-sigma) is an integral membrane protein. It can promote oligomerization by binding to large heparan sulfate proteoglycan structures, and interact with NTRK1/3, PPFIA1/2/3 (PMID: 25385546; 8524829; 9624153). The non-glycosylated molecular weight of PTPRS is 214 kDa, and the extracellular domain can be cleaved near the cell membrane by an endoprotease to generate a glycated 140 kDa protein. Variations and mutations of PTPRS are associated with Alzheimer's disease and cholangiocarcinoma (PMID: 38766183; 35991009).