PTPRS Rekombinanter Antikörper

PTPRS Rekombinant Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

CloneNo.

241005B6

Kat-Nr. : 83833-5-RR

Synonyme

Receptor-type tyrosine-protein phosphatase S, R PTP sigma, R PTP S, PTPSIGMA, EC:3.1.3.48

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  WB analysis using 83833-5-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 83833-5-RR (rPTPσ antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours.

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  Affinity and Kinetic Characterization of 83833-5-RR

  Biolayer interferometry (BLl) kinetic assays of 83833-5-RR against Human PTPRS were performed. The affinity constant is 68.9 pM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: A431-Zellen, SH-5Y5Y cells

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:5000-1:50000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

83833-5-RR bindet in WB, ELISA PTPRS und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Fusionsprotein
• Vollständiger Name: protein tyrosine phosphatase, receptor type, S
• Berechnetes Molekulargewicht: 217 kDa
• Beobachtetes Molekulargewicht: 140 kDa, 217 kDa
• GenBank-Zugangsnummer: NM_002850
• Gene symbol: PTPRS
• Gene ID (NCBI): 5802
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Protein tyrosine phosphatase receptor type S (PTPRS, also known as R-PTP-S, PTPSIGMA, and R-PTP-sigma) is an integral membrane protein. It can promote oligomerization by binding to large heparan sulfate proteoglycan structures, and interact with NTRK1/3, PPFIA1/2/3 (PMID: 25385546; 8524829; 9624153). The non-glycosylated molecular weight of PTPRS is 214 kDa, and the extracellular domain can be cleaved near the cell membrane by an endoprotease to generate a glycated 140 kDa protein. Variations and mutations of PTPRS are associated with Alzheimer's disease and cholangiocarcinoma (PMID: 38766183; 35991009).