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Pentraxin 3 Rekombinanter Antikörper

Pentraxin 3 Rekombinant Antikörper für WB, Cytometric bead array, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Cytometric bead array, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241393D3

Kat-Nr. : 84096-3-PBS

Synonyme

PTX3, 241393D3, Pentaxin related protein PTX3, Pentaxin-related protein PTX3, Pentraxin related protein PTX3

Filter:
  • Western Blot (WB) analysis of various lysates using Pentraxin 3 Recombinant antibody (84096-3-RR)

    WB analysis using 84096-3-RR (same clone as 84096-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84096-3-RR (Pentraxin 3 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84096-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84096-3-RR

    Affinity and Kinetic Characterization of 84096-3-RR

    Biolayer interferometry (BLl) kinetic assays of 84096-3-RR against Human Pentraxin 3 were performed. The affinity constant is 0.701 nM.

Geprüfte Anwendungen

Produktinformation

84096-3-PBS bindet in WB, Cytometric bead array, Indirect ELISA Pentraxin 3 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Pentraxin 3 fusion protein Eg1303
Vollständiger Name pentraxin-related gene, rapidly induced by IL-1 beta
Berechnetes Molekulargewicht42 kDa
Beobachtetes Molekulargewicht 42 kDa
GenBank-ZugangsnummerNM_002852.4
Gene symbol Pentraxin 3/PTX3
Gene ID (NCBI) 5806
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Pentraxin 3 (PTX3), also known as TNF-inducible gene 14 protein (TSG-14), is a member of the pentraxin superfamily which consists of evolutionarily conserved proteins characterized by a structural motif99, the pentraxin domain (PMID: 15771574). Pentraxin 3 can be produced by a variety of cell types including endothelial cells, smooth muscle cells, adipocytes, fibroblasts, mononuclear phagocytes, and dendritic cells, and its expression is induced by primary inflammatory signals, such as IL-1, TNF, and microbial moieties (PMID: 15771574). Pentraxin 3 is an acute phase glycoprotein that plays a role in regulating innate resistance to pathogens, inflammation, tissue remodeling and repair, female fertility, and cancer (PMID: 29412047). Pentraxin 3 is a biomarker for cardiovascular disease (PMID: 22347626). Increased plasma Pentraxin 3 levels have been found in patients with cardiovascular disorders (PMID: 22347626; 31057548). In WB, there're two major bands, an upper signal at 80-86 kDa and a lower signal at 42 kDa, representing Pentraxin 3 dimers and monomers, respectively (PMID: 18223257).