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PWWP2B Polyklonaler Antikörper

PWWP2B Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 32112-1-PBS

Synonyme

PWWP Domain Containing 2, PWWP Domain Containing 2B , PWWP domain-containing protein 2B, PWWP2

Filter:
  • Western Blot (WB) analysis of various lysates using PWWP2B Polyclonal antibody (32112-1-AP)

    WB analysis using 32112-1-AP (same clone as 32112-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 32112-1-AP (PWWP2B antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32112-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

32112-1-PBS bindet in WB, Indirect ELISA PWWP2B und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen PWWP2B fusion protein Ag36839
Vollständiger Name PWWP domain containing 2B
Beobachtetes Molekulargewicht90 kDa
GenBank-ZugangsnummerBC068574
Gene symbol PWWP2B
Gene ID (NCBI) 170394
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PWWP2B (PWWP structural domain protein 2B) is a PWWP structural domain-containing protein involved in a variety of cellular functions and biological processes. PWWP2B is highly expressed in brown and beige adipose tissue and its expression is induced by cold stimulation. It has been shown that PWWP2B negatively regulates adipose tissue thermogenesis by recruiting and stabilizing the histone deacetylase HDAC1/2, which binds to the promoter regions of thermogenic genes and reduces histone acetylation levels. In adipocytes, PWWP2B acts as part of the nucleosome remodeling and deacetylation complex (NuRD) to inhibit the expression of thermogenic genes and avoid overactivation of thermogenic functions. In addition, PWWP2B plays an important role in DNA damage repair, as its PWWP structural domain moves to DNA damage sites, interacts with UHRF1 and recruits MRE11 to promote DNA end resection and homologous recombination repair. In pathology, downregulation of PWWP2B is associated with recurrent gastric cancer and promotes cell proliferation and migration.