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Phospho-ASK1 (Ser966) Polyklonaler Antikörper

Phospho-ASK1 (Ser966) Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 28846-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using Phospho-ASK1 (Ser966) Polyclonal antibody (28846-1-AP)

    WB analysis using 28846-1-AP (same clone as 28846-1-PBS)

    Non-treated NIH/3T3, phosphatase inhibitor treated and λ phosphatase treated NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 28846-1-AP (Phospho-ASK1 (Ser966) antibody) at dilution of 1:500 incubated at 4℃ overnight. This data was developed using the same antibody clone with 28846-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

28846-1-PBS bindet in WB, Indirect ELISA Phospho-ASK1 (Ser966) und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name mitogen-activated protein kinase kinase kinase 5
Berechnetes Molekulargewicht 155 kDa
Beobachtetes Molekulargewicht120 kDa
GenBank-ZugangsnummerBC054503
Gene symbol ASK1
Gene ID (NCBI) 4217
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ASK1(Apoptosis signal-regulating kinase 1) is also named as MAP3K5, MAPKKK5, MEKK5 and belongs to the MAP kinase kinase kinase subfamily. It is an evolutionarily conserved mitogen activated protein 3-kinase that activates both Jnk and p38 mitogen-activated protein kinases. ASK1 is is activated in response to various cytotoxic stresses including TNF, Fas and reactive oxygen species (ROS) such as H2O2, and activates c-Jun NH 2-terminal kinase (JNK) and p38. The predicted MW of ASK1 is around 155 kDa and the 110-120 kDa fragment has also been reported.