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Phospho-AXL (Tyr779) Rekombinanter Antikörper

Phospho-AXL (Tyr779) Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242719C12

Kat-Nr. : 82816-4-PBS

Synonyme

AXL, EC:2.7.10.1, Tyrosine-protein kinase receptor UFO, UFO

Filter:
  • Western Blot (WB) analysis of A172 cells using Phospho-AXL (Tyr779) Recombinant antibody (82816-4-RR)

    WB analysis of A172 using 82816-4-RR (same clone as 82816-4-PBS)

    Non-treated A172 cells and pervanadate treated A172 cells were subjected to SDS PAGE followed by western blot with 82816-4-RR (Phospho-AXL (Tyr779) antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with Alpha Tubulin (66031-1-Ig) antibody as a loading control. This data was developed using the same antibody clone with 82816-4-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

82816-4-PBS bindet in WB, Indirect ELISA Phospho-AXL (Tyr779) und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name AXL receptor tyrosine kinase
Berechnetes Molekulargewicht 894 aa, 98 kDa
Beobachtetes Molekulargewicht140 kDa
GenBank-ZugangsnummerBC032229
Gene symbol AXL
Gene ID (NCBI) 558
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Axl, also known as Ufo or Ark, is a receptor tyrosine kinase of the TAM (Tyro3, Axl and Mer) family. Phospho-AXL (Tyr779) refers to the phosphorylated form of the receptor tyrosine kinase AXL at tyrosine 779 within its intracellular kinase domain. Upon ligand binding (e.g., Gas6 or HGF), AXL dimerizes and undergoes trans-autophosphorylation, generating phospho-Tyr779 that serves as a docking site for the p85 regulatory subunit of PI3K, thereby activating the PI3K/AKT/mTOR pathway and promoting cell survival, migration, and invasion. (PMID: 28251492)